Eskiocak O*, Gewolb J*, Shah V*, Rouse J*, Chowdhury S*, Akyildiz O.A, Fernández-Maestre I, Boyer J.A., Filliol A, Harris A, Utama R, Guo G, Castro-Hernández C, Nnuji-John E, Chung C, Anderson A, Flowers S, Habel J, Romesser P, Levine R, Lowe S, Sadelain S, Beyaz S, Amor C. Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness. Nat Aging. (2025).
Gomez A, Wu Y, Zhang C, Boyd L, Wee T, Gewolb J, Amor C, Cheadle L, Borniger, J.C. A brain-body feedback loop driving HPA-axis dysfunction in breast cancer. Neuron. 10.1016/j.neuron.2025.11.019 (2025). More info
Thaiss C.A., Tian Y, Winer D.A., Linterman M, Liston A, Amor C, Lowe S.W., Liu, G. Voices: Aging and Immunity. Immunity. 58,1-4 (2025).
Maestre-Fernández I, Harris A, Amor C. Aging and Immunity: the age-old tango. Genes Dev. 39;948-974 (2025).
Boyer JA, Sharma M, Dorso M, Mai N, Amor C, Reiter JM, Kannan R, Gadal S, Xu J, Miele M, Zhuoning L, Chen X, Chang Q, Pareja F, Worland S, Warner D, Sperry S, Chiang GG, Thompson PA, Yang G, Ouerfelli O, De Stanchina E, Wendel HG, Rosen EY, Chandarlapaty S, Rosen N. eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer. Proc Natl Acad Sci. 122; e2424286122 (2025).
Guo G & Amor C. SGLT2 regulates immune-mediated senolysis. Nat Aging. 4;909-910 (2024).
Murga M, Lopez-Pernas G, Soliva R, Fueyo E, Amor C , Faustino I, Serna M, González A, Díaz L, Martínez S, Blanco C, Anton, M.E., Pastor J, Jafari R, Lafarga M, Llorca O, Orozco M, Fernández-Capetillo O. SETD8 inhibiton targets cancer cells with increased rates of ribosome biogénesis. Cell Death Dis. 15; 694 (2024).
Eskiocak O*, Chowdhury S*, Shah V*, Nnuji-John E, Chung C, Boyer J.A., Harris A, Habel J, Sadelain M, Beyaz S, Amor C. Senolytic CAR T cells reverse age-induced defects in intestinal regeneration and fitness. BioRxiv (2024). More info
Amor Cγ, Fernandez-Maestre I, Chowdhury S, Graham C, Nnuji-John E, Feucht J, Boyer J, Mezzadra R, Wereski M.G, Levine R, Jones L.W., Sadelain M., Lowe S.W. Senolytic CAR T cells reverse and prevent age-related metabolic dysfunction. Nat Aging. DOI: 10.1038/s43587-023-00560-5. (2024). More info
γ Sole corresponding author.
Yashawini C, Qin T, Bhattacharya D, Amor C, Lowe S, Lujambio A, Wang S, Friedman S.L. Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatotic liver disease. J Hepatol. DOI: 10.1016/j.jhep.2024.03.014 (2024).
Leibold J*, Tsanov K*, Amor C*, Ho Yu-Jui, Sanchez-Rivera F, Feucht J, Baslan T, Chen H, Tian S, Simon J, Wuest A, Wilkinson J, Lowe S. Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease. Nat Cancer. 5; 315-329 (2024). More info
Amor C*, Feucht J*, Leibold J*, Ho Y, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer J.A, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman S.L, Ponomarev V, Piersigili A, Sadelain M*, Lowe S.W*. Senolytic CAR T cells restore tissue homeostasis in senescence-associated pathologies. Nature.583; 127-132 (2020). More info
Leibold J, Ruscetti M, Cao Z, Ho Y, Baslan T, Zhou M, Abida W, Feucht J, Han T, Barriga F.M, Tsanov K.M, Zamechek-Slain L, Kulick A, Amor C, Tian S, Rybczyk K, Salgado N.R, Sanchez-Rivera F.J, Watson P.A, Stanchina E, Wilkinson J.E, Dow L.E, Abate-Shen C, Sawyers C.L., Lowe, S.W. Somatic tissue engineering in mouse models reveals an actionable role for WNT pathway alterations in prostate cancer metastasis. Cancer Discovery. 10; 1038-1057 (2020). More info
Meng F, Du Z, Federation A, Hu J, Wang Q, Kieffer-Kwon K, Meyers RM, Amor C, Wasserman C, Neuberg D, Nussenzweig MC, Casellas R, Bradner JE, Liu XS, Alt FW. Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability. Cell. 159; 1538-1548 (2014). More info