Publications

Eskiocak O*, Chowdhury S*, Shah V*, Nnuji-John E, Chung C, Boyer J.A., Harris A, Habel J, Sadelain M, Beyaz S, Amor C. Senolytic CAR T cells reverse age-induced defects in intestinal regeneration and fitness. BioRxiv (2024). More info

Amor Cγ, Fernandez-Maestre I, Chowdhury S, Graham C, Nnuji-John E, Feucht J, Boyer J, Mezzadra R, Wereski M.G, Levine R, Jones L.W., Sadelain M., Lowe S.W. Senolytic CAR T cells reverse and prevent age-related metabolic dysfunction. Nat Aging. DOI: 10.1038/s43587-023-00560-5. (2024). More info
γ Sole corresponding author.

  • Highlighted in: Bartley & Xu. Nat.Aging.(2024).

Yashawini C, Qin T, Bhattacharya D, Amor C, Lowe S, Lujambio A, Wang S, Friedman S.L. Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatotic liver disease. J Hepatol. DOI: 10.1016/j.jhep.2024.03.014 (2024).

Leibold J*, Tsanov K*,  Amor C*, Ho Yu-Jui, Sanchez-Rivera F, Feucht J, Baslan T, Chen H, Tian S, Simon J, Wuest A, Wilkinson J, Lowe S. Somatic mouse models of gastric cancer reveal genotype-specific  features of metastatic disease. Nat Cancer. 5; 315-329 (2024). More info

Amor C*, Feucht J*, Leibold J*, Ho Y, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer J.A, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman S.L, Ponomarev V, Piersigili A, Sadelain M*, Lowe S.W*. Senolytic CAR T cells restore tissue homeostasis in senescence-associated pathologies. Nature.583; 127-132 (2020). More info

  • Highlighted in: Nature: (Nature .583; 37-38 (2020)), Nature Reviews Drug Discovery (https://www.nature.com/articles/d41573-020-00117-w), Nature Medicine (Nat.Med .26;1009 (2020)), Nature Reviews Immunology (Nat Rev Immunol.29;459 (2020)), Nature Reviews Nephrology (Nat Rev Nephrol.16,458 (2020)), Cancer Discovery (10.1158/2159-8290.CD-RW2020-098), Science Translational Medicine (Sci Transl Med. 12; 550. (2020)) and Cell Stem Cell (Cell Stem Cell. 27;192-194 (2020).

Leibold J, Ruscetti M, Cao Z, Ho Y, Baslan T, Zhou M, Abida W, Feucht J, Han T, Barriga F.M, Tsanov K.M, Zamechek-Slain L, Kulick A, Amor C, Tian S, Rybczyk K, Salgado N.R, Sanchez-Rivera F.J, Watson P.A, Stanchina E, Wilkinson J.E, Dow L.E, Abate-Shen C, Sawyers C.L., Lowe, S.W. Somatic tissue engineering in mouse models reveals an actionable role for WNT pathway alterations in prostate cancer metastasis. Cancer Discovery. 10; 1038-1057 (2020). More info

Meng F, Du Z, Federation A, Hu J, Wang Q, Kieffer-Kwon K, Meyers RM, Amor C, Wasserman C, Neuberg D, Nussenzweig MC, Casellas R, Bradner JE, Liu XS, Alt FW. Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability. Cell. 159; 1538-1548 (2014). More info